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KMID : 0882420070730030299
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Korean Journal of Medicine
2007 Volume.73 No. 3 p.299 ~ p.306
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Is cardiovascular disease more common in Vietnam veterans exposed to agent orange?
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Kang Won-Yu
Kim Han-Kyun
Jeong Myung-Ho
Cho Sang-Cheol
Jeong An-Duk
Cho Yong-Chan
Ki Young-Hwa
Lee Bong-Kyu
Hwang Sun-Ho
Kim Weon
Kim Wan
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Abstract
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Background : TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), a material of agent orange, was reported as a deadly
poison in spite of its presence at extremely small doses. It has been reported that TCDD can cause various kinds of
cancers and harmful effects on humans. However, a correlation between exposure to TCDD and cardiovascular disease
is not yet known. Thus, we intended to examine the correlation between TCDD exposure and cardiovascular disease
through an analysis of coronary angiograms in veterans of the Vietnam War.
Methods : A consecutive 115 patients undergoing coronary angiograms between April 2004 and June 2005 at Gwangju Veterans Hospital were analyzed. The patients were divided into two groups: 57 patients exposed to TCDD (Group I, average age 59.2±4.2 years) and 58 patients that were not exposed to TCDD (Group II, Average age 60.1±5.6 years). The clinical and coronary angiographic findings were evaluated.
Results : Baseline clinical characteristics, inflammatory markers and echocardiographic parameters were not different between patients in the two groups. The incidence of diabetes (43.9% vs. 25.0%, p=0.035) and hyperlipidemia (47.4% vs.27.6%, p=0.028) were higher in group I patients than group II patients. Significant coronary artery stenosis was more common in group I (45 cases, 78.9%) thanin group II (33 cases, 56.9%) (p=0.011).
Conclusion : There was a higher incidence of diabetes, hyperlipidemia, and significant coronary artery stenosis in patients that underwent a diagnostic coronary angiogram that were previously exposed to TCDD.(Korean J Med
73:299-306, 2007)
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KEYWORD
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Drugs, Coronary diseases, Angioplasty
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